I've been experimenting with a sort of "bare bones" layout with articles for a few weeks now. I have a half-dozen websites using the layout and the average Adsense Page RPM is $18.50 USD. To answer the obvious question, no these aren't articles that use ridiculously high paying no-chance-for-the-little-guy-to-compete-competition keywords either.
Basically, it's a 500-600 word article centered on the page with some navigation links on top, a descriptive heading, a paragraph of introduction text, a 728x90 advertisement, the entire article text, then some links to other articles and websites on the bottom.
There are no layout graphics at all in this layout, only an occasional article-relevant graphic within the article text from time to time. No sidebars, navigation is kept above the heading, and down in the footer. I haven't been adding any links within the article text to relevant articles.
There are 3 sizes of black text, normal, h1, and h2 sizes. The background is solid white and the links are the default blue. The main heading is centered, the rest of the text is left-aligned within the centered 800 pixel column.
The websites use almost no bandwidth, CPU to generate the pages is minimal.
It will be interesting to see if this layout survives, it really does give new meaning to "content is king".